Long-term Outcomes (15 Years) After Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

Objective To evaluate the effects of deep brain stimulation subthalamic nucleus (STN-DBS) on motor complications in patients with Parkinson disease (PD) beyond 15 years after surgery. Methods Data complications, quality life (QoL), activities daily living, Unified Parkinson’s Disease Rating Scale scores, dopaminergic treatment, measures, and side STN-DBS were retrospectively retrieved compared before surgery, at 1 year, bilateral STN-DBS. Results Fifty-one 17.06 ± 2.18 follow-up recruited. Compared to baseline, time spent dyskinesia “off” state reduced by 75% ( p < 0.001) 58.7% 0.001), respectively. Moreover, drugs 50.6% 0.001). Parkinson's Quality Life Questionnaire total score emotional function social domains improved 13.8% = 0.005), 13.6% 0.01), 29.9% Few mostly manageable device-related adverse events observed during follow-up. Conclusions is effective from intervention, notably significant improvement stable reduction drugs. Furthermore, despite natural continuous progression PD worsening levodopa-resistant nonmotor symptoms over years, undergoing could maintain an QoL. Classification Evidence This study provides Class IV evidence that, for PD, remains treating